Romanian Youth Voice

PhD position in Molecular Science, Supelec, France

A PhD scholarship has been announced by CEA in association with Supelec. The PhD scholarship aims its research area in Molecular biophysics / Life Sciences/Biochemistry / Life Sciences.



Title: Study of proteins involved in the regulation of Manganese homeostasis by advanced High-Field Electron Paramagnetic Resonance spectroscopy.



Abstract: The LMESS is a state-of-the-art high-field electron paramagnetic resonance (HFEPR) laboratory interested in the study of manganese in biological systems. Mn is an essential element but exposition to high levels is related to neurodegenerative diseases. Mn also determines the degree of virulence of several. However, how Mn is transported inside the cell and transferred to specific proteins is by far less understood than for other metals. We propose the study of the MntR protein that regulates Mn uptake in cells by binding to specific DNA regions. MntR binds two Mn(II) ions per monomer and it has been shown to adopt different conformations.

More information on:
http://www-dsv.cea.fr/en/institutes/institute-of-biology-and-technology-saclay-ibitec-s

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30.01.2011. 20:41

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